Effect of SOF/VEL Antiviral Therapy for HCV Treatment

A Control Theoretic Approach

Keywords: HCV, SOF/VEL, Optimal control problem, Sensitivity analysis, Efficiency analysis, Cost-effectiveness


Liver cirrhosis and hepatocellular carcinoma disease caused by the Hepatitis C virus (HCV) infection. Inside this article, a deterministic model has been formulated and analyzed for the transmission of HCV in the liver cells. We have also considered two types of viral strain (wild and mutant).  We have also projected a mathematical model of the effect of Sofosbuvir  (SOF) together with Velpatasvir (VEL) antiviral therapy in HCV infected patients. Our analytical and numerical findings reveal that the optimal schedule of treatment for the best result should be obtained by choosing the best strategy depending on the circumstances.

How to Cite
Mondal, Jayanta, Piu Samui, and ChatterjeeAmar Nath. 2021. “Effect of SOF/VEL Antiviral Therapy for HCV Treatment”. Letters in Biomathematics 8 (1), 191–213. https://lettersinbiomath.journals.publicknowledgeproject.org/index.php/lib/article/view/435.