Comparison of Screening for Methicillin-Resistant Staphylococcus Aureus at Hospital Admission and Discharge

  • Cole Butler North Carolina State University
  • Jinjin Cheng College of Science, Shanghai University
  • Lorena Correa Universidad Yachay Tech
  • María R. Preciado-Rivas Yachay Tech University
  • Andrés Ríos-Gutiérrez Universidad Nacional de Colombia
  • César Montalvo Arizona State University
  • Christopher Kribs University of Texas at Arlington
Keywords: MRSA, screening strategies, infection control, search and isolation, mathematical model


Methicillin-resistant Staphylococcus aureus (MRSA) contributes greatly to the growing concern of antibiotic-resistant bacteria, especially given its stubborn persistence in healthcare settings. MRSA resists treatment and has colonized an estimated 2% of people worldwide. The CDC reports MRSA prevalence as high as 25–50% in countries like the U.K. and the U.S. Given its resistant nature—it evolves to compensate antibiotic treatment—controlling MRSA levels requires precautionary and defensive measures. This study examines the "search and isolation" approach, which seeks to isolate MRSA-positive patients in hospitals to decrease transmission. Although this strategy is straightforward, whom to screen may vary in practice. We compare screening at admission to screening at discharge, using a mathematical model whose simulations determine MRSA endemic levels in a hospital under either control measure. We found screening at discharge more effective in controlling MRSA endemicity, but at the cost of more isolated patients.

Author Biographies

Lorena Correa, Universidad Yachay Tech

Escuela de Ciencias Matemáticas y Tecnología Informática

María R. Preciado-Rivas, Yachay Tech University

School of Physical Sciences and Nanotechnology

Andrés Ríos-Gutiérrez, Universidad Nacional de Colombia

Department of Statistics

César Montalvo, Arizona State University

Simon A. Levin Mathematical Computational and Modeling Sciences Center

Christopher Kribs, University of Texas at Arlington

Professor, Department of Mathematics

How to Cite
Butler, Cole, Jinjin Cheng, Maria Correa, Preciado-RivasMaría, Ríos-GutiérrezAndrés, César Montalvo, and Christopher Kribs. 2021. “Comparison of Screening for Methicillin-Resistant Staphylococcus Aureus at Hospital Admission and Discharge”. Letters in Biomathematics 8 (1), 151–166.