The concentration of digoxin after intravenous and oral administration studied by a two-compartment model

  • V. Siva Rama Krishna Reddy Gokaraju Rangaraju Institute of Engineering and Technology
  • K. Lakshmi Narayan Vidya Jyothi Institute of Technology
Keywords: Compartment model, eigenvalue, laplace transform, residual, digoxin, oral, intravenous, normal subjects

Abstract

The present paper is designed to compare the distribution of digoxin administered through an Intravenous (i.v.) and Oral (p.o.) in central and peripheral compartments. The model under consideration is denoted by a system of three non-linear ordinary differential equations. The Eigenvalue and the Laplace transform methods were used to solve the system of equations. In this model, digoxin was administered to three subjects through i.v. and three subjects through p.o. then, the serum concentrations were measured over a period of 6 h. The transfer coefficients were obtained from digoxin concentrations using the method of residuals and the variation of digoxin concentration–time curves plotted using MATLAB. In this model, we consider excretion is only from the peripheral compartment.

Published
2019-09-20
How to Cite
Siva Rama Krishna Reddy, V., and K. Lakshmi Narayan. 2019. “The Concentration of Digoxin After Intravenous and Oral Administration Studied by a Two-Compartment Model”. Letters in Biomathematics 6 (2), 1-15. https://doi.org/10.1080/23737867.2019.1653233.
Section
Research