# A Mathematical model of Malaria transmission dynamics with general incidence function and maturation delay in a periodic environment

### Abstract

In this paper, we investigate a mathematical model of malaria transmission dynamics with maturation delay of a vector population in a periodic environment. The incidence rate between vector and human hosts is modeled by a general nonlinear incidence function which satisfies a set of conditions. Thus, the model is formulated as a system of retarded functional differential equations. Furthermore, through dynamical systems theory, we rigorously analyze the global behavior of the model. Therefore, we prove that the basic reproduction number of the model denoted by *R*_{0} is the threshold between the uniform persistence and the extinction of malaria virus transmission. More precisely, we show that if *R*_{0} is less than unity, then the disease-free periodic solution is globally asymptotically stable. Otherwise, the system exhibits at least one positive periodic solution if *R*_{0} is greater than unity. Finally, we perform some numerical simulations to illustrate our mathematical results and to analyze the impact of the delay on the disease transmission.

*Letters in Biomathematics*7 (1), 37–54. https://lettersinbiomath.journals.publicknowledgeproject.org/index.php/lib/article/view/223.